Where it differs mainly is that you have the potential to change weapons on each level in Nuclear Throne, and mutations allow for permanent buffs to your chosen character. Nuclear Throne is a less forgiving game and it could be argued that more skill is required to beat a run. Nuclear Throne is a top-down dungeon crawler much like The Binding of Isaac, and there are a number of different characters to choose from, too. Rogue Legacy 2 is also a good option if you end up liking the first instalment, but it doesn’t quite reach the heights of its predecessor, in my opinion. It’s true that Rogue Legacy isn’t quite as varied as Isaac (in terms of synergies, characters, and enemies), but it in many ways it has a more tangible sense of progression, and you can feel the levelling up process from run to run. It’s built on the same run progression mindset as TBOI, has cutesy and simple graphics, and has ultra addictive gameplay. If you liked TBOI, there’s a strong likelihood you may also have a good time with Rogue Legacy. What are the Best Games Like The Binding of Isaac? 5.